This article details the five candidates who raised the most money and lost their election. In the 2022 election cycle, 96 of 150 general elections were contested. The losing candidates are shown along with the percentage of the vote they received compared to the winner. In cases where the race was pushed to a runoff, vote percentages for both advancing candidates are included.

LaMantia is running to represent Texas State Senate District 27 in 2022. LaMantia raised $695,670 and spent $3.9 million between Jan. 1, 2021, and June 30, 2022. According to Texas Ethics Commission reports, LaMantia spent the most money with the following individual payees and PACs.