This article details the five candidates who raised the most money and lost their election. In the 2022 election cycle, 78 of 99 general elections were contested. The losing candidates are shown along with the percentage of the vote they received compared to the winner. In cases where the race was pushed to a runoff, vote percentages for both advancing candidates are included.

Across the Buckeye State, donors are contributing large sums to candidates and committees hoping to claim victories in the perennial swing state. This year, many of the top 10 donors in Ohio are supporting parties, candidates, and committees who are attempting to win key state-level legislative and judicial races.