This article details the five candidates in each party who raised the most money and lost their primary election. In the 2022 election cycle, 15 of 49 Republican primaries and seven of 37 Democratic primaries were contested. The losing candidates are shown along with the percentage of the vote they received compared to the primary winner. In cases where the race was pushed to a runoff, vote percentages for both advancing candidates are included.

Across all contested Republican primary elections, candidates raised $1.8 million. Incumbents raised an average of $111,949 per candidate and challengers raised an average of $35,619 per candidate.