This article details the five candidates who raised the most money and lost their election. In the 2022 election cycle, 17 of 25 general elections were contested. The losing candidates are shown along with the percentage of the vote they received compared to the winner. In cases where the race was pushed to a runoff, vote percentages for both advancing candidates are included.

Elections for 25 of 50 seats in the Indiana State Senate will take place on November 8, 2022. State senatorial primary elections are held on May 3, 2022. Republicans hold a 39-11 majority heading into the election.