This article details the five candidates who raised the most money and lost their election. In the 2022 election cycle, 17 of 25 general elections were contested. The losing candidates are shown along with the percentage of the vote they received compared to the winner. In cases where the race was pushed to a runoff, vote percentages for both advancing candidates are included.

In Indiana, state-level candidates spent $11.2 million between Jan. 1, 2021, and Apr. 8, 2022. Democratic candidates spent $1.56 million and Republican candidates spent $9.25 million. 

Across all contested Democratic primary elections, candidates raised $494,264. Incumbents raised an average of $21,805 per candidate and challengers raised an average of $40,969 per candidate.