This article details the five candidates who raised the most money and lost their election. In the 2022 election cycle, 37 of 50 general elections were contested. The losing candidates are shown along with the percentage of the vote they received compared to the winner. In cases where the race was pushed to a runoff, vote percentages for both advancing candidates are included.

In North Carolina, the list of the top fundraisers in the state is dominated by the Governor, Attorney General, and Lieutenant Governor, each of whom reported in excess of $9.5 million in contributions. Taking his place just after those prominent statewide officeholders in North Carolina is Republican State Sen. Jim Perry.