This article details the five candidates who raised the most money and lost their election. In the 2022 election cycle, 59 of 67 general elections were contested. The losing candidates are shown along with the percentage of the vote they received compared to the winner. In cases where the race was pushed to a runoff, vote percentages for both advancing candidates are included.

General elections for all 67 districts in the Minnesota State Senate took place on Nov. 8, 2022. Of the 67 districts up for election in 2022, 59 had a General election with more than one candidate.

In Minnesota, state-level candidates have spent $40.4 million between Jan. 1, 2021, and Oct. 24, 2022. Democratic candidates have spent $22.4 million and Republican candidates have spent $17 million.