This article details the five candidates who raised the most money and lost their election. In the 2022 election cycle, 109 of 110 general elections were contested. The losing candidates are shown along with the percentage of the vote they received compared to the winner. In cases where the race was pushed to a runoff, vote percentages for both advancing candidates are included.

General elections for all 110 districts in the Michigan House of Representatives took place on Nov. 8, 2022. Of the 110 districts up for election in 2022, 109 had a General election with more than one candidate.

General elections for all 38 districts in the Michigan State Senate took place on Nov. 8, 2022. Of the 38 districts up for election in 2022, 38 had a General election with more than one candidate.